一般人群中n-3長鏈多不飽和脂肪酸和全因死亡風險的薈萃分析
Scientific Reports雜誌近期發表了一項關於增加飲食n-3長鏈多不飽和脂肪酸 (LCPUFA) 的攝入或提高循環血液中的n-3長鏈多不飽和脂肪酸的水平降低全因死亡風險的薈萃分析文章。
該研究採用隨機效應模型,對11個包括371 965參與者的前瞻性研究進行了計算分析。結果發現:膳食n-3長鏈多不飽和脂肪酸攝入較高的人群和攝入較低的人群相比全因死亡風險下降9%。進一步的量效分析顯示: 長鏈n-3多不飽和脂肪酸攝入量每日增加0.3克,伴有6%的全因死亡風險的下降; 而循環血液中EPA和DHA與總脂肪酸中的比值每增加1%,分別伴有20%和21% 的全因死亡風險的下降。
圖片來源:百度圖庫
原文:
N-3 long-chain polyunsaturated fatty acids and risk of all-cause mortality among general populations: a meta-analysis
Abstract
Prospective observational studies have shown inconsistent associations of dietary or circulating n-3 long-chain polyunsaturated fatty acids (LCPUFA) with risk of all-cause mortality. A meta-analysis was performed to evaluate the associations. Potentially eligible studies were identified by searching PubMed and EMBASE databases. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random-effects model. Eleven prospective studies involving 371 965 participants from general populations and 31 185 death events were included. The summary RR of all-cause mortality for high-versus-low n-3 LCPUFA intake was 0.91 (95% CI: 0.84-0.98). The summary RR for eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) intake was 0.83 (95% CI: 0.75-0.92) and 0.81 (95% CI: 0.74-0.95), respectively. In the dose-response analysis, each 0.3 g/d increment in n-3 LCPUFA intake was associated with 6% lower risk of all-cause mortality (RR?=?0.94, 95% CI: 0.89-0.99); and each 1% increment in the proportions of circulating EPA and DHA in total fatty acids in blood was associated with 20% (RR?=?0.80, 95% CI: 0.65-0.98) and 21% (RR?=?0.79, 95% CI: 0.63-0.99) decreased risk of all-cause mortality, respectively. Moderate to high heterogeneity was observed across our anlayses. Our findings suggest that both dietary and circulating LCPUFA are inversely associated with all-cause mortality.
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