肺炎支原體感染與兒童哮喘的關係研究

肺炎支原體感染與兒童哮喘的關係研究

The study of correlation between mycoplasma pneumoniainfection and asthma in children

馮帥,陳波,李芳君,尹曉文,等

投稿時間：2016-08-23

中文關鍵詞：肺炎支原體 兒童 哮喘

基金項目：國家自然科學基金(21567024)

作者單位：石河子大學醫學院,新疆 石河子 832000 （馮帥）石河子大學醫學院第一附屬醫院兒科,新疆 石河子 832002 （陳波）石河子大學醫學院第一附屬醫院兒科,新疆 石河子 832002 （李芳君）石河子大學醫學院第一附屬醫院兒科,新疆 石河子 832002（尹曉文）

通訊作者：E-mail：[email protected]

【中文摘要】目的 探討肺炎支原體(MP)感染與兒童哮喘的關係,為兒童哮喘的臨床診治提供參考依據。方法 選取2012年6月—2015年6月收治的118例哮喘發作患兒,採用酶聯免疫吸附法檢測入組兒童血清中肺炎支原體抗體(MP-IgM),比較其感染MP-IgM的陽性率,並分析哮喘患兒支原體感染的臨床特點。結果 118例哮喘發作患兒中,由呼吸道感染因素、過敏因素、運動因素、其他因素誘發的分別為89例(75.4%)、14例(11.9%)、9例(7.6%)、6例(5.1%)；呼吸道感染因素誘發中由細菌感染、病毒感染、MP感染誘發的分別為26例(29.3%)、19例(21.3%)、44例(49.4%)；118份哮喘患兒血清學標本中,MP-IgM 陽性血清標本44份,陽性率為37.3%；哮喘兒童性別比較,女性患兒MP-IgM陽性率高於男性患兒,差異有統計學意義(χ2=4.182,P=0.041)；不同年齡段MP-IgM陽性率比較,學齡前期哮喘患兒MP感染陽性率最高,為48.4%,高於嬰幼兒組和學齡期組,三組間差異有統計學意義(χ2=6.882,P=0.032)；具有特應性體質的哮喘患兒MP-IgM陽性率明顯高於不具有特應性體質患兒,差異有統計學意義(χ2=5.497,P=0.019)。結論 MP感染是兒童哮喘發作的重要誘發因素,MP感染誘發哮喘與性別、年齡及宿主的特應質體質有關。

【英文摘要】Objective To explore the correlation between mycoplasma pneumonia infection and asthma in children,and provide reference for the prevention,diagnosis and treatment of asthma.Methods From June 2012 to June 2015,8 cases of children with asthma were chosen,passive agglutination method with Mycoplasma pneumoniae enzyme-linked immunosorbent assay were used to test positive rate of antibody (MP-IgM) and analyzed clinical features of mycoplasma infection in asthmatic children.Results For 118 cases of children with asthma,the case number induced by respiratory tract infection factors by allergic,sports and other factors were 89 cases (75.4%),14 cases (11.9%),9 cases (7.6%),6 cases (5.1%),respectively;infection by bacteria,virus and,MP infection were 26 cases (29.3%),19 cases (21.3%),44 cases (49.4%);118 serum samples of children with asthma,44 serum samples were MP-IgM positive,the positive rate was 37.3%;for comparison of asthma children′s gender,the positive rate of female children of MP-IgM was higher than that of male patients,the difference was statistically significant (χ2=4.182,P=0.041);for comparison the positive rate of MP-IgM between different age groups,the positive rate of asthma in preschool children with MP infection were 48.4%,which was the highest,and there were statistically significant differences between the three groups (χ2=6.882,P=0.032);MP positive rate of atopic asthma physical children was higher than the children without constitution atopic children,with a statistically significant difference (χ2=5.497,P=0.019).Conclusion Mycoplasma pneumoniae infection is an important predisposing factor of asthma in children,Mycoplasma pneumoniae infection was influenced by the children gender,age and host atopic constitution.

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