病毒學公開課系列之九：Reverse Transcription and Integration

引 言

為提高病毒學研究者，尤其是在讀研究生的專業水平和英語水平，病毒學界將定期推送國內外大學的病毒學相關的公開課內容。本次為第九期：逆轉錄與整合(哥倫比亞大學，全英文)

演講題目：Reverse Transcription and Integration

演講者：Prof. Vincent Racaniello, Ph.D.

演講者單位：哥倫比亞大學

內容簡介：主要講解了病毒RNA逆轉錄為DNA，以及病毒DNA整合至宿主基因組的過程，圖文並茂，適合中級進階者學習專業知識和練習英文之用。

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精彩內容展示：

首先簡述了一下腫瘤病毒及逆轉錄的發現史：逆轉錄的發現是對分子生物學的中心法則進行修正和補充。

隨後是介紹了具有逆轉錄功能的兩類病毒：逆轉錄病毒（包括HIV）和乙肝病毒（HBV）

以逆轉錄病毒為例，介紹了逆轉錄合成DNA過程以及整合至宿主基因組過程：

以HBV為例，介紹了HBV逆轉錄的形式（HBV沒有基因組整合）：

附 Vincent R. Racaniello教授簡介

Prof.Vincent R. Racaniello (born January 2, 1953 in Paterson, New Jersey) is a Higgins Professor in the Department of Microbiology and Immunology at Columbia University』s College of Physicians and Surgeons. He is one of four virologists who has recently authored Principles of Virology, a textbook used by many teaching virology to undergraduate, medical and graduate students.

As an esteemed member of the scientific community, Racaniello has received several awards including Irma T. Hirschl, Searle Scholars, Eli Lilly and NIH Merit. He has also been a Harvey Society Lecturer at Rockefeller University, the Hilleman Lecturer at the University of Chicago, and University Lecturer at Columbia University. Racaniello has served on the editorial boards of scientific journals, including the Journal of Virology, and is a community editor for the open access journal PLOS Pathogens. He also served as the 2015 president of the American Society for Virology.

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