研究人員發現，細菌- 銅綠假單胞菌（一種引起肺炎，敗血症和其他感染的病原體）在一組細菌內傳達遇難信號，以響應某些抗生素。發現這種溝通在整個殖民地有所不同，並表明這種細菌可能會產生保護行為，這有助於其耐受某些抗生素的能力。研究結果表明，微生物可能具有某些保護菌落免受某些外部毒素的能力，即使它仍處於殖民階段。報道的行為是由妥布黴素引起的，這是一種臨床常用的抗生素，導致雙重信號反應。由於這種抗生素被應用於P.aeruginosa的菌落，細菌產生了一個信號到殖民地的局部區域 - 一個已知會發生的假單胞菌喹諾酮信號（PQS）以及第二個全社區響應，稱為烷基羥基喹啉（AQNO）。該研究已發表在「生物化學雜誌」上。

Bacteria gang up to thwart antibiotics

Researchers have found that the bacterium, Pseudomonas aeruginosa — a pathogen that cause pneumonia, sepsis and other infections — communicates distress signals within a group of bacteria in response to certain antibiotics. This communication was found to vary across the colony and suggests that this bacterium may develop protective behaviours which contribute to its ability to tolerate some antibiotics. The findings reveal that the microbe may have some capability to protect the colony from some external toxins even as it continued to be in a colonising phase. The reported behaviour was caused by tobramycin, an antibiotic commonly used in clinical settings, and resulted in a dual signal response. As this antibiotic was applied to a colony of P.aeruginosa, the bacteria produced a signal to a localised area of the colony — a Pseudomonas quinolone signal (PQS) that is known to occur as well as a second, community-wide response, known as the alkyl hydroxyquinoline (AQNO). The study has been published in the Journal of Biological Chemistry.

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