一種腸病毒71疫苗在中國的安全性、有效性和免疫原性研究 An Enterovirus 71 Vaccine

國內多地爆發手足口病、皰疹性咽峽炎疫情，一起學習中國江蘇學者Fengcai Zhu等，在新英格蘭雜誌發表的相關文章吧！

【Efficacy, Safety, and Immunogenicity of an Enterovirus 71 Vaccine in China一種腸病毒71疫苗在中國的安全性、有效性和免疫原性研究】

Enterovirus n.腸病毒

Immunogenicity n.免疫原性

Aluminum n.鋁

Hydroxide n.氫氧化物

Herpangina n.皰疹性咽峽炎

Enterovirus 71(EV71) is an important cause of hand, foot, and mouth disease, especially in China. This trial evaluated the efficacy, safety, and immunogenicity of EV71 vaccine, the Vero cell–based EV71 inactivated vaccine with aluminum hydroxide. During the 12-month surveillance period, EV71-associated disease was identified in 0.3% of vaccine recipients (13 of 5041 children) and 2.1% of placebo recipients (106 of 5028 children). The vaccine efficacy against EV71-associated hand, foot, and mouth disease or herpangina was 94.8% in this cohort. Vaccine efficacies against EV71-associated hospitalization (0 cases vs. 24 cases) and hand, foot, and mouth disease with neurologic complications ( 0 cases vs. 8 cases) were both 100%. Serious adverse events occurred 2.2% in the vaccine group and 2.6% in the placebo group. In the immunogenicity subgroup, an anti-EV71 immune response was elicited by the two-dose vaccine series in 98.8% of participants at day 56. The EV71 vaccine provided protection against EV71-associated hand, foot, and mouth disease or herpangina in infants and young children.1

【譯文】腸病毒71（EV71）是手足口病的重要病因，特別是在中國。本研究評估了以Vero cell為基礎氫氧化鋁滅活EV71疫苗的有效性、安全性和免疫原性。在12個月監察期中，EV71相關疾病出現在0.3%的疫苗接種者（13/5041兒童）和2.1%的安慰劑接種者（106/5028兒童）中。本隊列研究中，該疫苗針對EV71相關手足口病或者皰疹性咽峽炎的有效性為94.8%。針對EV71相關住院（例對24例）和手足口病神經系統併發症（例對8例），疫苗的有效性均為100%。疫苗組中發生嚴重不良事件為2.2%，安慰劑組中為2.6%。免疫原性亞組中，連續兩次疫苗接種引起抗EV71免疫反應，接種56天時出現在98.8%的疫苗接種者。EV71疫苗為嬰幼兒提供針對EV71相關手足口病或者皰疹性咽峽炎的保護。

【醫學單詞記憶之道】

1.醫學單詞記憶

herpes皰疹

herpesvirus n.皰疹病毒

herpangina n.皰疹性咽峽炎

herpes simplex單純皰疹

herpes zoster帶狀皰疹

2.常用醫學片語

hand, foot and mouth disease手足口病

aluminum hydroxide氫氧化鋁

adverse event不良事件

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