炎性痛(IB)特點以及與AS患者疾病活動度

炎性痛(IB)或神經痛(NP)：

特點以及與AS患者疾病活動度

和功能狀態的關聯

目 的

評估中軸型脊柱關節炎（axSpA）患者的炎性背痛（IBP）和神經性疼痛（NP），並探討其與疾病活動度和功能狀態的關係。

方 法

評估IBP或NP的存在、疼痛強度和性質、疼痛干擾、疾病活動度和功能狀態。 使用單變數分析和二元邏輯回歸法確定與IBP或NP相關的因素。

結 果

50名患者（37.9％）患有IBP，22名患者（16.7％）患有NP。 IBP或NP患者的疼痛強度和疼痛干擾、疾病活動度和功能受限的評分顯著高於無IBP或NP的患者（P <0.05）。 IBP或NP的性質主要通過感覺描述詞表述，IBP患者在情感描述方面具有較高的「疲憊感」（P <0.05）。 IBP與疾病活動度之間存在顯著相關性（比值比[OR] = 1.813,95％置信區間[CI] = 1.196-2.750）。 NP與功能受限相關（OR = 1.544,95％CI = 1.098-2.171）。

結 論

儘管IBP或NP患者的疼痛性質（感覺和情感疼痛描述）有差異，合併IBP或NP的axSpA患者均痛感更強、干擾更劇烈、疾病活動度更高、功能受限更明顯。在axSpA患者中，合併IBP或NP均反映了更高的疾病活動度和更明顯的功能受限。

原 文

Inflammatory or Neuropathic Pain: Characteristics and

Their Relationships with Disease Activity and Functional Status in Axial Spondyloarthritis Patients.

Objective

To assess inflammatory back pain (IBP) and neuropathic pain (NP) in patients with axial spondyloarthritis (axSpA) and explore their relationships with disease activity and functional status.

Methods

The presence of IBP or NP, pain intensity and quality, pain interference, disease activity, and functional status were assessed. Univariate analyses and binary logistic regressions were used to identify factors related to IBP or NP.

Results

Fifty patients (37.9%) had IBP, and 22 (16.7%) had NP. Scores of pain intensity and pain interference, disease activity, and functional limitation were significantly higher in patients with IBP or NP than those without either (P<0.05). The quality of IBP or NP was mainly presented as sensory descriptors, and patients with IBP had a higher level of "tiring-exhausting" in affective descriptors (P<0.05). There was a significant correlation between IBP and disease activity (odds ratio [OR] = 1.813, 95% confidence interval [CI] = 1.196-2.750). NP was related to functional limitation (OR=1.544, 95% CI = 1.098-2.171).

Conclusion

Though pain quality (sensory and affective pain descriptors) show differently in patients with IBP or NP, the axSpA patients with IBP or NP experience more severe pain intensity and pain interference, higher disease activity, and greater functional limitation. The presence of IBP or NP could reflect higher disease activity or greater functional limitation in patients with axSpA.

文章出處：

Ji Y, et al., Pain Med. 17 Jul 2018.

https://www.ncbi.nlm.nih.gov/pubmed/30020521

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