人類基因組編輯國際峰會組委會回應基因編輯嬰兒事件
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來源:BioArtReports微信公眾號
人類胚胎基因組編輯委員會
大會組委會聲明
在第二屆人類基因組編輯國際峰會(香港)即將召開之際,大會組委會獲悉,中國誕生了一對被胚胎基因組編輯的雙胞胎,而領導這項研究的賀建奎研究員也即將在本次峰會(周三)上發言。
可遺傳的基因組編輯臨床試驗,一直是許多研究小組爭論和探討的熱點話題,目前已經有大量的研究證據,為進行可遺傳的基因組編輯臨床試驗提供了有力的理論證據和研究基礎。美國國家科學院、工程與醫學科學院2017年發表的報告中寫道,在臨床前研究充分闡明潛在的風險和益處,並且通過同行評審的情況下,這類的臨床研究可能會被批准。但這僅僅是在沒有更有效的治療手段情況下,人們選擇更先進醫學手段的方式,但不得不提到的是,這些研究提供的手段只是一類可以選擇的替代方式,而在臨床研究進行的整個過程中,必須要做到高度的透明化,並且需要經歷嚴格的監督和審查。此外,報告還提到,在進行這類研究時,我們應該保持謹慎的態度,同時需要廣泛徵求社會公眾的意見和建議,並且在相關部門制定了有效的監管手段(包括研究的標準和結構體系)的情況下,這項研究才是真正有意義和科學的。
讓我們將目光放到歐洲。2018年英國納菲爾德生物倫理學委員會發布了一份獨立調查報告,這份報告明確指出「我們應該建立一個高效的遺傳性基因組編輯的干預環境」,這樣才能保證人類遺傳基因編輯的安全性。而在中國,導致了這兩個孩子出生的臨床試驗是否符合相關標準,還有待商榷。
大會組委會希望通過這次高峰論壇的對話,可以進一步增進全世界對人類基因組編輯相關研究問題和倫理問題的認識和理解,而我們的目標是確保人類基因組編輯安全、合理、有效且負責地進行,並且造福全社會。
聯繫方式:
莫莉·高爾文(Molly Galvin)
公共信息和新聞辦公室
美國國科學院院,工程與醫學院
電子郵箱:mgalvin@nas.edu
聯繫電話: +1-202-731-2841
聲明原文如下:
Nov。 26, 2018
Statement from the Organizing Committee on Reported Human Embryo Genome Editing
HONG KONG -- On the eve of the Second International Summit on Human Genome Editing, we were informed of the birth of twins in China whose embryonic genomes had been edited。 The researcher who led the work, He Jainkui, is scheduled to speak at the summit on Wednesday。
The criteria under which heritable genome-editing clinical trials could be deemed permissible have been the subject of much debate and discussion by many research groups。
Numerous studies have provided guidance for the conduct of heritable genome-editing clinical trials。 One such study, a 2017 report by the U.S。
National Academies of Sciences, Engineering, and Medicine, concluded that clinical trials might be permitted after peer-reviewed preclinical research further clarifies the potential risks and benefits, only for compelling medical reasons in the absence of reasonable alternatives, and with maximum transparency and strict oversight。 The report noted that such research should be approached with caution and with broad public input。
It specified a regulatory framework that included ten recommended criteria and structures。 A second major report, released in 2018, which was the result of an independent inquiry by the Nuffield Council on Bioethics in the U.K。, also specifies 「circumstances in which heritable genome editing interventions should be permitted。」
Whether the clinical protocols that resulted in the births in China conformed with the guidance in these studies remains to be determined。
We hope that the dialogue at our summit further advances the world』s understanding of the issues surrounding human genome editing。
Our goal is to help ensure that human genome editing research be pursued responsibly, for the benefit of all society。
Contact:
Molly Galvin
Office of News and Public Information
U.S。 National Academies of Sciences, Engineering, and Medicine
mgalvin@nas.edu
Mobile: +1-202-731-2841
聲明原文:http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=11262018
會議日程如下:
(賀建奎處高亮)
AGENDA
http://www.nationalacademies.org/hk/index.html
Tuesday, 27 November 2018
7:30 a.m。
Registration/LightBreakfast
8:30 a.m。
Welcome,Introductions, and Opening Remarks
Moderator:
Summit OrganizingCommittee Chair DavidBaltimore,* CaliforniaInstitute of Technology
Speech:
The Hon。 Mrs。 Carrie Lam, Chief Executive, Hong Kong SpecialAdministrative Region
Opening Remarks:
Lap-Chee Tsui, The Academy of Sciences of Hong Kong
John Skehel,* The Royal Society
Victor J。 Dzau, U.S。 National Academy of Medicine
9:00 a.m。
Genes, Genomes, andGenetic Variation
Moderator:
Kathryn Song Eng Cheah, The University of Hong Kong
Speakers:
John Christodoulou, The University of Melbourne
Pak C。 Sham, University of Hong Kong
Dana Carroll, University of Utah
10:00 a.m。
Discussion withAudience
10:30 a.m。
Break
11:00 a.m。
Social andPhilosophical Reflections on Manipulating Genetic Variation
Moderator:
Kazuto Kato,* Osaka University
Speakers:
Renzong Qiu, Chinese Academy of Social Science
Mohammed Ghaly, Hamad Bin Khalifa University
Maurizio Balistreri, Università degli Studi di Torino
Satoshi Kodama, Kyoto University
MargaretSleeboom-Faulkner, University of Sussex
12:30 p.m。
Discussion withAudience
1:00 p.m。
Lunch
2:00 p.m。
The Science of HumanGenome Editing
Moderator:
Duanqing Pei,* Guangzhou Institutes of Biomedicine andHealth
Speakers:
Feng Zhang, Broad Institute
David R。 Liu, Broad Institute
Angelo Lombardo, San Raffaele University
Jennifer Doudna,* University of California, Berkeley
3:15 p.m。
Discussion withAudience
3:45 p.m。
Break
4:15 p.m。
Update: GovernmentalActions and Advisory Opinions Regarding Human Genome Editing
Moderator:
Jennifer Merchant,* Université Panthéon-Assas Paris
Speakers:
Xiaomei Zhai,* Chinese Academy of Medical Sciences and Peking Union Medical College
Hervé Chneiweiss, Centre National de la RechercheScientifique, France
S。 R。 Rao, Ministry of Science and Technology,Government of India
Hidenori Akutsu, National Research Institute for Child Health and Development
Dianne Nicol, University of Tasmania
Tamra Maree Lysaght, National University of Singapore
Lot Chan, Hong Kong Special Administrative Region
6:00 pm
Discussion with Audience
6:30 pm
Adjourn
Wednesday, 28 November 2018
8:00 a.m。
Registration/LightBreakfast
8:30 a.m。
Welcome and Overview of Day』s Program
Summit OrganizingCommittee Chair David Baltimore,* CaliforniaInstitute of Technology
8:35 a.m。
Current Research and Clinical Applications: Pathways to Translation
Moderator:
Y。 M。 Dennis Lo, The Chinese University of Hong Kong
Speaker:
George Q。 Daley,* Harvard Medical School
9:00 a.m。
Discussion with Audience
9:20 a.m。
Blood Disorders –Basic and Translational Research
Moderator:
BeverleyFrancis-Gibson, Sickle Cell DiseaseAssociation of America, Inc。
Speakers:
Merlin Crossley, University of New South Wales, Sydney
Sivaprakash Ramalingam, Institute of Genomics and IntegrativeBiology
Matthew Porteus,* Stanford University
Junjiu Huang, Sun Yat-sen University
Vence L。 Bonham, National Human Genome Research Institute
10:35 a.m。
Discussion withAudience
11:00 a.m。
Break
11:30 a.m。
Human Embryo Editing
Moderator:
Robin-Lovell-Badge,* The Francis Crick Institute
Speakers:
Kathy Niakan, The Francis Crick Institute
Paula Amato, Oregon Health & Science University
Maria Jasin, Memorial Sloan Kettering Cancer Institute
Xingxu Huang, Shanghai Tech University
Jiankui He, Southern University ofScience and Technology
12:30 pm
Discussion with Audience
1:00 pm
Lunch
2:15 pm
Genome Editing ofHeritable Diseases: Technical and Societal Considerations
Moderator:
Richard O。 Hynes, Massachusetts Institute of Technology
Speakers:
Adrian Thrasher, University College London
R。 Rodney Howell, University of Miami
Charles A。 Gersbach, Duke University
Pauline McCormack, Newcastle University
3:15 pm
Discussion withAudience
3:45 pm
Break
4:15 pm
Human Genome Editing:Research Ethics
Moderator:
R。 Alta Charo,* University of Wisconsin, Madison
Speakers:
B?rbel Friedrich, German National Academy of SciencesLeopoldina
Andy Greenfield, Medical Research Council
Jeffrey Kahn, Johns Hopkins University
TetsuyaIshii, Hokkaido University
Eben Kirksey, Deakin University
5:30 pm
Discussion with Audience
6:00 pm
Adjourn
Thursday, 29 November 2018
7:30 a.m。
Registration/Light Breakfast
8:00 a.m。
Welcome and Overview of Day』s Program
Summit OrganizingCommittee Chair David Baltimore,* CaliforniaInstitute of Technology
8:10 a.m。
Global Perspectives: Somatic and Germline Therapy, Prevention, and Enhancement Applications
Moderator:
Ayo Wahlberg, University of Copenhagen
Speakers:
Kevin G。 Behrens, University of the Witwatersrand
Guido de Wert, Maastricht University
Peter Mills, Nuffield Council on Bioethics
Yuko Harayama, Tohoku University
9:10 a.m。
Discussion with Audience
9:30 a.m。
Identifying BasicPrinciples for Moving Forward
Moderator:
María de Jesús MedinaArellano, National AutonomousUniversity of Mexico
Speakers:
Sarah Chan, University of Edinburgh
Ames Dhai, University of the Witwatersrand
J。 Benjamin Hurlbut, Arizona State University
Ock-Joo Kim, Seoul National University
10:30 a.m。
Discussion with Audience
11:00 a.m。
Break
11:30 a.m。
Public Engagement Efforts
Moderator:
Jennifer Doudna,* University of California, Berkeley
Speakers:
Anna Middleton, Wellcome Sanger Institute
Joy Y。 Zhang, University of Kent
Megan Munsie, University of Melbourne
Masako Takuma, National Museum of Emerging Science andInnovation
12:15 pm
Discussion with Audience
12:45 pm
Concluding Remarks from the Organizing Committee
1:00 pm
Discussion with Audience
1:30 pm
Adjourn
*Member of Summit Organizing Committee
Second International Summit on Human Genome Editing Breakout Sessions
I。 Breakout Session on Embryo and GermlineEditing: A Forward Look at Research, Application, and Governance
Thursday, November 29, 2018
2:15-4:45 pm
Grand Hall, Lee Shau Kee Lecture Centre, The University of Hong Kong
In conjunction with the Second International Summit on Human Genome Editing, this breakout session will focus on the use of genome editing in human embryos and germline cells。 The session will provide an opportunity for a more in-depth discussion of the research presented during the summit, an opportunity to discuss other relevant research, and an opportunity to discuss the potential use of genome editing to make alterations that may be heritable。
The session will include presentations from local researchers as well as from researchers around the world。
Light lunch will be available 45 minutes prior to this event。
AGENDA
Session Co-chairs:
Robin Lovell Badge,* The Francis Crick Institute
Duanqing Pei,* Guangzhou Institutes of Biomedicine andHealth
2:15-3:00 pm
Panel 1
Speakers:
Maria Jasin, Sloan Kettering Institute – Trust inScience, Scientists and the Role of Journals
Kathy Niakan, The Francis Crick Institute – The Unknowns of Early Human Development and the Impact on Genome Editing
Xingxu Huang, ShanghaiTech University: To DevelopBase-Editing Platforms for Correction of Pathogenic Mutations in Human Embryos
3:00-3:15 pm
Panel Discussion
3:15-4:00 pm
Panel 2
Speakers:
Jiankui He, Southern University of Science andTechnology – The Roadmap towards Developing Standards for Safety and Efficacy for Human Germline Gene Editing and Moral Principles
Helen O』Neill, University College London – Forging a Bench to Clinical Pipeline in Human Germline Editing
Judith Daar, University of California, Irvine School of Law – The Ethics of Germline Genome Editing: The Role of Consent Among theUnavailable and Unborn
4:00-4:15 pm
Panel Discussion
4:15-4:45 pm
Plenary Discussion
II。 Let』s Talk About Genomics and Genome Editing
Thursday, November 29, 2018
6:30-9:30 pm
The Wang Gungwu Lecture Hall, Graduate House, The University of Hong Kong
This event is designed to provide members of the public with a generalintroduction to genomics and genome editing。 It will provide participants withan opportunity to consider scientific and ethical questions related to the useof genome editing and engage in a conversation with experts on these topics。
The event will be simultaneously translated from English into Cantonese。
Light refreshments will be provided。
AGENDA
6:30 pm
Registration and LightRefreshments
6:45 pm
Welcome
Victor J。 Dzau, President, U.S。 National Academy of Medicine
6:55 pm
Introduction to HumanGenomics
Speaker:
Clara Tang, The University of Hong Kong
7:20 pm
Introduction to GenomeEditing
Speaker:
Robin Lovell-Badge,* The Francis Crick Institute
7:50 pm
Break
8:00 pm
Public Engagement onBiosciences in China
Speaker:
Joy Zhang, University of Kent
8:20 pm
Public Engagement onHuman Genome Editing in the UK
Speaker:
Sarah Chan, The University of Edinburgh
8:40 pm
Audience Discussion ofHuman Genome Editing
9:30 pm Adjourn
※互聯網太老了,支撐不起高速發展的現實世界
※中國晶元差在哪?這篇講全了
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